MedChecker: Medicines Interactions Checker

We have successfully developed a software program for monitoring/analyzing these Drug-Drug & Drug-Herb Interactions. And we are on course to incorporate the MedChecker® into EMDEX 2018.

See the sample Amiodarone Interaction monograph below.

AMIODARONE / AZITHROMYCIN Interaction Monograph
Object drug Amiodarone
Precipitant Azithromycin
Severity Severe
Mechanism Azithromycin may enhance the QTc-prolonging effect of Amiodarone.
Effects Co-administration of Amiodarone and Azithromycin may result in additive QTc prolongation or other serious cardiac events e.g., torsades de pointes (TdP), cardiac arrest. The risk is further worsened in patients with cardiac disease, electrolyte imbalance, elderly, etc.
Recommendations The use of Azithromycin with Class III antiarrhythmic agents generally should be avoided. Most health facilities may not have adequate facilities to monitor the cardiac function closely
References:

  1. Lexicomp Online®, Drug interactions, Hudson, Ohio: Lexi-Comp, Inc.; November 25, 2017.
  2. Sweetman S (Ed), Martindale: The complete drug reference. London: Pharmaceutical Press. Electronic version; November 25, 2017.
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